This lab introduces the computational and quantitative tools underlying contemporary bioinformatics. Students explore the various approaches to phylogenetic reconstruction using molecular data, methods of data mining in genome databases, comparative genomics, structure-function modeling and the use of molecular data to reconstruct population and evolutionary history. Students are encouraged to explore datasets of particular interest to them. Corequisite: BIO 334. Enrollment limited to 16.

This course focuses on methods and approaches in the emerging fields of bioinformatics and molecular evolution. Discussions include the quantitative examination of genetic variation, selective and stochastic forces shaping proteins and catalytic RNA, comparative analysis of whole genome data sets, comparative genomics and bioinformatics, and hypothesis testing in computational biology. The course explores the role of bioinformatics and comparative methods in the fields of molecular medicine, drug design and in systematic, conservation and population biology. Corequisite: BIO 335.

Instrument specific course highly recommended for students interested in using state-of-the-art microscopy techniques in research (special studies, honors, SURF, etc.). Participants get exposure to basic and advanced light and electron microscopy techniques available at Smith. Mechanical and optical components are reviewed. Operational parameters for improving image quality and data collection using digital imaging and image analysis techniques are discussed.

Offered as BIO 308 and NSC 308. Formerly BIO 310. Molecular level structure-function relationships in the nervous system. Topics include development of neurons and glia, neuron-specific gene expression, molecular biology of neurological disorders and the mechanisms of nervous system plasticity and repair. Prerequisites: BIO 200 and NSC 210 or equivalent. Enrollment limited to 20.

An introduction to the immune system covering the molecular, cellular and genetic bases of immunity to infectious agents. Discussions include immunodeficiencies, transplantation, allergies, immunopathology and immunotherapies. Concurrent registration in BIO 307 recommended. Prerequisite: BIO 202, BIO 204 or BIO 230.

This lab introduces students to plant morphology and identification through hands-on work with plant material. In addition, the class focuses on local native plants and the outstanding botanical collections in the Lyman Plant House. Includes field trips to other sites of botanical interest in the region. Corequisite: BIO 264. Enrollment limited to 20.

This laboratory examines relationships between invertebrate form and function and compares diversity within and among major body plans using live and preserved material. Students observe and document invertebrate structure, life cycles, locomotion, feeding and other behaviors. Corequisite: BIO 260. Enrollment limited to 20.

Invertebrate animals account for the vast majority of species on earth. Although sometimes inconspicuous, invertebrates are vital members of ecological communities. They provide protein, important ecosystem services, biomedical and biotechnological products, and aesthetic value to humans. Today, many invertebrate populations are threatened by human activities. This course surveys the extraordinary diversity and importance of invertebrates, emphasizing their form and function in ecological and evolutionary contexts. Corequisite: BIO 261. Enrollment limited to 20.

A laboratory designed to give students an introduction to genomics and the molecular biology of genetics. Students gain experience with a variety of classical and modern techniques used in human genetic analysis and several experiments using students' DNA are performed throughout the semester. Laboratory and computer-based projects include PCR, restriction analysis and DNA sequencing as well as contemporary bioinformatics and genome database analyses. Prerequisite: BIO 230 or BIO 232, normally taken concurrently. Enrollment limited to 16.