This course, intended for students with a background in physical, chemical, or quantitative life science, will cover physical principles that apply to biological molecules and cells: Bownian motion, low Reynolds-number environments, forces relevant to cells and molecules, chemical potentials and free energies, as well as the basics of polymer physics. The emphasis will be on theory and model-building; specific topics will include molecular machines, self-assembly, membranes, DNA, and RNA.