Man has used breeding programs for the last 3000 years to increase yields of plants, to incorporate specific traits into farm animals and pets. Early motivation was probably first survival then commerce. Early tools were based in careful observation. Today, we have biotechnology: the ability to genetically engineer almost any organism. The ability to change and/or create any bio-molecule, drug, antibiotic, fuel or crop is almost at our fingertips. But what will make it happen?