Skeletal Muscle Bioenergetics

Non-invasive 31P Magnetic resonance spectroscopy (MRS) measurements of the kinetics of pH and phosphorylated metabolites contain valuable information about muscle energy flux, metabolic control, mitochondrial function and cellular pH homeostasis in vivo, but quantitative interpretation depends on understanding the underlying physiology. In this class, through some literature reading and by using existing dataset, students will establish an analytical framework to quantitatively estimate energy flux, mitochondrial function and proton handling in skeletal muscle using MRS-based methodology.
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